Johnson & Johnson COVID-19 Vaccine Induces Strong T-Cell Response To Variants : Shots


A girl receives the Johnson & Johnson COVID-19 at a drive-in vaccination occasion final week in Meerbusch, Germany.

Lukas Schulze/Getty Photographs

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Lukas Schulze/Getty Photographs

A girl receives the Johnson & Johnson COVID-19 at a drive-in vaccination occasion final week in Meerbusch, Germany.

Lukas Schulze/Getty Photographs

The emergence of recent and extra infectious variants of the coronavirus has raised a troubling query: Will the present crop of COVID-19 vaccine forestall these variants from inflicting illness?

A research out Wednesday within the journal Nature suggests the reply is sure.

The analysis was pretty simple. Scientists took blood from volunteers who had acquired the Johnson & Johnson COVID-19 vaccine and seemed on the ranges of neutralizing antibodies, the type that forestall a virus from getting into cells.

“What we confirmed is that the neutralizing antibodies are lowered about fivefold to the B.1.351 variant,” says Dan Barouch, director of the Middle for Virology and Vaccine Analysis at Beth Israel Deaconess Medical Middle in Boston. Beneath the brand new nomenclature proposed by the World Well being Group, B.1.351 is now referred to as Beta. It first appeared in South Africa.

“That is similar to what different investigators have proven with different vaccines,” he says. “However what we additionally confirmed is that there is many different sorts of immune responses aside from neutralizing antibodies, together with binding antibodies, FC practical antibodies and T-cell responses.”

And it is that final immune response, the T-cell response, that Barouch says is critically necessary. As a result of T cells, notably CD8 T cells, play an important position in stopping sickness.

“These are the killer T cells,” Barouch says. “These are the sorts of T cells that may principally hunt down and destroy cells which might be contaminated and assist clear an infection immediately.”

They do not forestall an infection; they assist preserve an an infection from spreading.

“The T-cell responses really should not lowered — in any respect — to the variants,” Barouch says. It isn’t simply the Beta variant, but additionally the Alpha and Gamma variants.

That will assist clarify why the Johnson & Johnson vaccine prevented severe illness when examined in volunteers South Africa, the place worrisome variants are circulating.

“The info could be very strong,” says Alessandro Sette, an immunologist on the La Jolla Institute for Immunology. “Dan Barouch’s knowledge actually present very properly that there is no such thing as a considerable lower in [CD8 T-cell] reactivity.”

Sette’s lab has had related outcomes with the Pfizer-BioNTech and Moderna COVID-19 vaccines. So has Marcela Maus at Massachusetts Common Hospital. Though it’s going to take research in folks to make certain the vaccines will work in opposition to variants, “Something that generates a T-cell immune response to the SARS-CoV-2, I might say has promise as being doubtlessly protecting,” Maus says.

What’s not clear but is how lengthy the T-cell response will final, however a number of labs are working to reply that query.


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